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Previously we have shown by electron microscopy that the extracellular domain of siv gp41 which is analogous to that of hiv forms high molecular weight aggregates in vitro and we have postulated that such high molecular weight aggregates are responsible for.
Important in cell cell recognition.
Appears to function in leukocyte endothelial cell adhesion.
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Iron is the most abundant transition metal in biology and an essential cofactor for many cellular enzymes.
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During the past years much effort has been paid to understand the molecular mechanism involved in maintaining systemic iron homeostasis in mammals.
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Iron homeostasis impairment is also a component of peripheral neuropathies.
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The vcam1 itga4 itgb1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Accumulation of the hiv envelope protein gp41 is observed in the brain tissues of patients suffering from hiv associated dementia.
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Interacts with integrin alpha 4 beta 1 itga4 itgb1 on leukocytes and mediates both adhesion and signal transduction.
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Iron is the most abundant transition metal in biology and an essential cofactor for many cellular enzymes.